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Objective To evaluate the effect of methylprednisolone sodium succinate combined with tropisetron on postoperative nausea and vomiting(PONV)under microvascular decompression of hemifacial spasm.Methods From January to June 2019,485 patients undergoing microvascular decompression for facial spasm at Department of Neurosurgery,Peking University People's Hospital were randomly assigned into two groups with random number table method.For group A(n=242),2 ml saline was administrated by intravenous drip before induction and 5 mg tropisetron after operation.For group B(n=243),40 mg methylprednisolone sodium succinate was administrated by intravenous drip before induction and 5 mg tropisetron after operation.The anesthesia time,operation time,and incidence of PONV in 0-24 h and 24-48 h were recorded for the comparison of the remedial treatment rate of nausea and vomiting between the two groups.Results There was no significant difference in age,gender,smoking history,body mass index value,American Society of Anesthesiologists score,medical history,surgical side,PONV history,operation time or anesthesia time between the two groups(all P > 0.05).The incidence of PONV in group A was 35.5% and 18.2% during 0-24 h and 24-48 h,respectively,which was significantly higher than that(18.5%,χ
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Humans , Antiemetics , Double-Blind Method , Hemifacial Spasm/surgery , Indoles , Methylprednisolone Hemisuccinate/therapeutic use , Microvascular Decompression Surgery , TropisetronABSTRACT
Objective:To investigate the effects of different doses of dexmedetomidine combined with tramadol on intravenous analgesia and sleep quality after cesarean section.Methods:One hundred and twenty pregnant women who underwent cesarean section in Zhongshan Boai Hospital from March 2019 to July 2020 were selected. They were randomly divided into four groups, with 30 patients in each group. The patients in group Awere given patient controlled anesthesia with tramadol 800 mg+ tropisetron 5mg after cesarean section, and the patients in group B1, B2 and B3 were given 1.0, 1.5, 2.0 μg/kg dexmedetomidine on the basis of group A. The scores of exercise and rest of visual analogue scale (VAS) at 6, 12, 24 and 48 h after the surgery were observed. The scores of Athens insomnia scale (AIS) before and after surgery were compared. The Ramsay sedation scores and basic vital signs were recorded, compared and analyzed at 6, 12, 24 and 48 h after the surgery. The incidence of adverse reactions within 48 h after the surgery was counted in the four groups.Results:The scores of exercise and rest of VAS at 6, 12, 24 and 48 h after the surgery in four groups had significant differences ( P<0.05). The scores of group A were the highest, and next were the group B1, B2 and B3. The scores of AIS at 1 and 2 d after surgery in four groups had significant differences ( P<0.05).The scores of group A were the highest, and next were the group B1, B2 and B3.The level of oxyhemoglobin saturation (SpO 2) after surgery in four groups had no significant difference ( P>0.05). The levels of systolicblood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) after surgery in four groups had significant differences ( P<0.05). The levels of SBP, DBP, HR in group A were the highest, and next were the group B1, B2 and B3. Thelevels of SBP, DBP, HR in group A, B1 and B2 were in normal range, but the levels of SBP, DBP and HR in group B3 were in lower limits of normal, the level of HR in some patients was below normal. The Ramsay sedation scores at 6, 12, 24 and 48 h after surgery in the four groups had significant differences ( P<0.05). Ramsay sedation scores in group A were the lowest, and next were the group B1, B2 and B3. The total incidence of adverse reactions in group B3 was the highest with 33.33%(10/30), and in group B1 was the lowest with 6.67%(2/30). Conclusions:Medium dose of dexmedetomidine (1.5 μg/kg) combined with tramadol has a good effect on postoperative intravenous sedation and analgesia in patients after cesarean section, which can improve the sleep quality of patients. Besides, the drug safety can be guaranteed.
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Tumors pose a great threat to human health. As a systemic treatment, chemotherapy has held an unshakable position in tumor treatment. Chemotherapy induced nausea and vomiting (CINV) is a common adverse reaction during chemotherapy, which seriously affects patients' mood, quality of life and tumor control. The prevention and treatment of CINV is very important for cancer patients. As a more commonly used 5-HT3 receptor antagonist, tropisetron has a good clinical effect in the prevention and treatment of CINV. However, there are still some patients who do not have a good effect after using tropisetron. More and more studies indicated that these individual differences might be closely related to genetic polymorphisms. In order to provide ideas for clinical individualized medication under the guidance of gene polymorphisms, this article reviewed the influence of CYP2D6 gene polymorphisms on the effect of tropisetron in preventing CINV.
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Objective To investigate the effect of sulfentanyl and tropisetron postoperative analgesia pump on perioperative interleukin 6(IL-6),tumor necrosis factor (TNF-α) and insulin resistance in patients undergoing abdominal general anesthesia.Methods From March 2016 to March 2017,120 patients undergoing elective abdominal surgery in our hospital were selected ,all patients were treated with general anesthesia.The patients were randomly divided into control group and observation group according to the digital table ,with 60 cases in each group.The control group was treated with on -demand delivery analgesia.The observation group was treated with sulfentanyl and tropisetron postoperative analgesia pump for postoperative analgesia.The BCS score,VAS score,Ramsay score at the end of operation and after operation were compared.The TNF-α,ISI,IL-6,insulin levels and blood glucose levels of preoperation and postoperation were compared between the two groups .Results Compared with the control group ,the BCS score and Ramsay score of postoperative 0.5d[(2.78 ±0.57) points,(2.27 ±0.39) points],postoperative 1d [(3.04 ±0.48)points,(2.36 ±0.50) points],postoperative 1.5d[(3.24 ±0.51) points,(2.43 ±0.49) points], postoperative 2d[(3.35 ±0.43) points,(2.51 ±0.42) points] in the observation group increased ( t＝-18.604,-8.65,-8.204,-3.967,t＝-9.634,-4.864,-4.610,-2.604,all P＜0.05),the VAS scores of postopera-tive 0.5d[(2.4 ±1.1) points],postoperative 1 d[(1.8 ±0.8) points],postoperative 1.5d[(1.7 ±0.5) points], postoperative 2d[(1.7 ±0.9)points] in the observation group were lower (t＝2.082,4.834,7.934,3.098,all P＜0.05).Compared with the control group ,the insulin,blood sugar,TNF-α,IL-6 of postoperative 0.5d[(7.26 ± 2.17)mU／L,( 5.63 ±0.58 ) mmol／L, ( 148.96 ±20.31 ) g／L, ( 120.54 ±22.27 ) pg／mL], postoperative 1d [(7.37 ±1.74)mU／L,(5.34 ±0.50)mmol／L,(121.35 ±21.07) μg／L,(116.35 ±21.01) pg／mL],postoperative 1.5d[(6.57 ±2.14)mU／L,(5.11 ±0.50)mmol／L,(114.36 ±23.99)μg／L,(113.14 ±18.05)pg／mL],postoper-ative 2d[(5.87 ±1.84)mU／L,(4.87 ±0.51) mmol／L,(100.02 ±18.13) μg／L,(91.37 ±14.88) pg／mL] in the observation group were lower ( t ＝9.374,11.698,6.455,10.161,t ＝8.557,13.027,9.990,8.541,t ＝6.730, 7.917,7.811,2.326,t＝8.003,7.225,3.839,-7.618,all P＜0.05).Compared with the control group ,the ISI of postoperative 0.5d[(24.77 ±0.26)×1 000],postoperative 1d[(25.03 ±0.21)×1 000], postoperative 1.5d [(29.65 ±0.17)×1 000],postoperative 2d[(34.54 ±0.19)×1 000] in the observation group were increased (t＝-281.912,-442.121,-248.226,-431.857,all P＜0.05).Conclusion The analgesic effect of sulfentanyl and tropisetron postoperative analgesia pump is good ,it can reduce the postoperative stress response and the levels of IL-6 and TNF-α,and reduce the degree of insulin resistance ,and can be widely used in clinical.
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Objective@#To investigate the effect of sulfentanyl and tropisetron postoperative analgesia pump on perioperative interleukin 6(IL-6), tumor necrosis factor (TNF-α) and insulin resistance in patients undergoing abdominal general anesthesia.@*Methods@#From March 2016 to March 2017, 120 patients undergoing elective abdominal surgery in our hospital were selected, all patients were treated with general anesthesia.The patients were randomly divided into control group and observation group according to the digital table, with 60 cases in each group.The control group was treated with on-demand delivery analgesia.The observation group was treated with sulfentanyl and tropisetron postoperative analgesia pump for postoperative analgesia.The BCS score, VAS score, Ramsay score at the end of operation and after operation were compared.The TNF-α, ISI, IL-6, insulin levels and blood glucose levels of preoperation and postoperation were compared between the two groups.@*Results@#Compared with the control group, the BCS score and Ramsay score of postoperative 0.5d[(2.78±0.57)points, (2.27±0.39)points], postoperative 1d[(3.04±0.48)points, (2.36±0.50)points], postoperative 1.5d[(3.24±0.51)points, (2.43±0.49)points], postoperative 2d[(3.35±0.43)points, (2.51±0.42)points] in the observation group increased (t=-18.604, -8.65, -8.204, -3.967, t=-9.634, -4.864, -4.610, -2.604, all P<0.05), the VAS scores of postoperative 0.5d[(2.4±1.1)points], postoperative 1 d[(1.8±0.8)points], postoperative 1.5d[(1.7±0.5)points], postoperative 2d[(1.7±0.9)points] in the observation group were lower (t=2.082, 4.834, 7.934, 3.098, all P<0.05). Compared with the control group, the insulin, blood sugar, TNF-α, IL-6 of postoperative 0.5d[(7.26±2.17)mU/L, (5.63±0.58)mmol/L, (148.96±20.31)g/L, (120.54±22.27)pg/mL], postoperative 1d[(7.37±1.74)mU/L, (5.34±0.50)mmol/L, (121.35±21.07)μg/L, (116.35±21.01)pg/mL], postoperative 1.5d[(6.57±2.14)mU/L, (5.11±0.50)mmol/L, (114.36±23.99)μg/L, (113.14±18.05)pg/mL], postoperative 2d[(5.87±1.84)mU/L, (4.87±0.51)mmol/L, (100.02±18.13)μg/L, (91.37±14.88)pg/mL] in the observation group were lower (t=9.374, 11.698, 6.455, 10.161, t=8.557, 13.027, 9.990, 8.541, t=6.730, 7.917, 7.811, 2.326, t=8.003, 7.225, 3.839, -7.618, all P<0.05). Compared with the control group, the ISI of postoperative 0.5d[(24.77±0.26)×1 000], postoperative 1d[(25.03±0.21)×1 000], postoperative 1.5d[(29.65±0.17)×1 000], postoperative 2d[(34.54±0.19)×1 000] in the observation group were increased (t=-281.912, -442.121, -248.226, -431.857, all P<0.05).@*Conclusion@#The analgesic effect of sulfentanyl and tropisetron postoperative analgesia pump is good, it can reduce the postoperative stress response and the levels of IL-6 and TNF-α, and reduce the degree of insulin resistance, and can be widely used in clinical.
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Objective To evaluate the efficacy and safety of tropisetron for the prevention of postoperative nausea and vomi -ting (PONV) after general anesthesia .Methods We searched the PubMed ,EBSCO ,Cochrane ,CNKI and Weipu database to identi-fy randomized controlled trials (RCT ) about tropisetron in preventing PONV after general anesthesia .The methodological quality of the included RCT was assessed and data were extracted .The meta-analyses were performed by Rev Man5 .0 software .Results A total of 18 RCT met the inclusion criteria ,involving 2 901 patients .All RCT were randomized double-blind experiments .The results of meta-analyses showed that :(1)tropisetron could significantly decrease the incidence of PONV after general anesthesia ,[OR =0 .43 ,95% CI(0 .33 - 0 .57)] ,the efficacy in later period [OR = 0 .41 ,95% CI(0 .25 - 0 .65)] was better than that in earlier period [OR = 0 .66 ,95% CI(0 .44 - 0 .98)] ;(2)compared with tropisetron ,the combination of tropisetron and dexamethasone could signifi-cantly decrease the incidence of PONV [OR = 0 .37 ,95% CI(0 .22 - 0 .64)] ;(3)compared with granisetron or ondansetron ,tropise-tron could not significantly decrease the incidence of PONV ,the OR was [OR = 1 .08 ,95% CI(0 .68 - 1 .73)] and [OR = 0 .77 ,95%CI(0 .27 - 2 .21)] respectively ;(4)compared with dexamethasone ,tropisetron could not significantly decrease the incidence of PONV [OR = 1 .06 ,95% CI(0 .49 - 2 .30)] .Conclusion Tropisetron can significantly decrease the incidence of PONV after general anesthesia .It has also the advantage of decreasing incidence of the incidence of PONV combined with other non-5 HT-3 receptor in-hibitor such as dexamethasone .
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Objective To compare the effects of a single injection of palonosetron and tropise-tron to prevent postoperative nausea and vomiting (PONV ) in gynecological surgeries. Methods Sixty patients undergoing elective major gynecological surgeries with general anesthesia (Apfel score ≥ 3 ) were included and randomized to group P (palonosetron ) and group T (tropisetron),30 patients in each group.All patients received general anesthesia with tracheal intuba-tion,and palonosetron 0.25 mg or tropisetron 5 mg were injected before anesthesia respectively in two groups.Intravenous hydromorphine was delivered for postoperative analgesia in all patients. PONV were evaluated and followed up for 72 hours.The degree of PONV was recorded and the com-plete response rate (CR)and complete control rate (CC)were calculated.Results The degree of PONV in 0-24 h and 24-48 h was milder in group P than in group T (P <0.05),while in 48-72 h the degree of PONV was similar between the two groups.In group P,5 patients had vomiting postopera-tively with the failure period of treatment of (1 9.6±9.4)h,and no patients needed rescue treatments. While in group T,1 9 patients suffered from vomiting with the failure period of treatment of (20.6± 4.5)h,and rescue treatments were delivered 3 times in total.The CR and CC of preventing PONV in 0-24 h,24-48 h and 0-72 h were significantly higher in group P than in group T (P <0.05).The CR and CC of the two groups were comparable in 48-72 h postoperatively.Conclusion A preoperative single dose of palonosetron 0.25 mg is better than tropisetron 5 mg in preventing PONV within 48hours after gynecological surgery.
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Objective To observe the efficacy and side effect of olanzapine combined with tropisetron, dexamethasone for the pre-vention of highly emetogenic chemotherapy-induced nausea and vomiting ( CINV) . Methods A total of 78 patients with highly emetogen-ic single day chemotherapy were randomly divided into two groups:trial group ( olanzapine combined with tropisetron, dexamethasone n=40) and control group (Tropisetron Combined with Dexamethasone n=38). The control of acute CINV, delayed CINV and adverse reac-tions were observed. Results The control rates of acute vomiting in trial group and control group were 87. 5% vs 81. 6%, 65. 0% vs 57. 9% in acute nausea, 75. 0% vs 52. 6% in delayed vomiting, 32. 5% vs 13. 2% in delayed nausea. The trial group was better than the control group in delayed vomiting and delayed nausea which there was difference between them (P 0. 05). Conclusion Olanzapine combined with tropisetron, dexa-methasone for the prevention was significantly better than tropisetron combined with dexamethasone in the control of delayed CINV in pa-tients received highly emetogenic chemotherapy.
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Objective To investigate the efficacy and safety of tropisetron combined with sulpiride in treatment of chemotherapy-induced cisplatin program nausea and vomiting,so as to explore the effect to motilin and gastrin.Methods A total of 84 patients with chemotherapy-induced cisplatin program nausea and vomiting were divided into study group (44 cases) and control group (40 cases) by random digits table method,the patients in two groups were given tropisetron hydrochloride intravenous injection,and the study group was added sulpiride.The efficacy and side effects and effect to motilin and gastrin were observed.Results The fully control rate and efficient rate in acute nausea was 59.09％ (26/44),37.50％ (15/40),and 90.91％ (30/44),72.50％ (29/40) in study group and control group,and there was significant difference (P ＜ 0.05).The fully control rate and efficient rate in acute vomiting was 61.36 ％ (27/44),37.50％ (15/40),and 88.64％ (39/44),67.50％ (27/40) in study group and control group,and there was significant difference (P ＜0.05).The fully control rate and efficient rate in delayed nausea was 54.54％ (24/44),32.50％ (13/40),and 79.55％ (35/44),57.50％ (23/40) in study group and control group,and there was significant difference (P ＜ 0.05).The fully control rate and efficient rate in delayed vomiting was 45.45 ％ (20/44),22.50％ (9/40),and 75.00％ (33/44),52.50％ (21/40) in study group and control group,and there was significant difference (P＜ 0.05).The plasma motilin after treatment was lower than that before treatment in study group and control group[(308.35 ± 14.59) ng/L vs.(370.59 ± 15.72) ng/L and(341.87 ± 18.38) ng/L vs.(365.36 ± 23.72) ng/L],gastrin was higher than that before treatment in study group and control group [(206.97 ± 12.29) ng/L vs.(164.56 ± 14.17) ng/L and (171.58 ± 13.53) ng/L vs.(158.42 ± 17.29) ng/L],and there was significant difference (P ＜ 0.05).There was significant difference in the plasma motilin and gastrin after treatment between two groups (P ＜ 0.05).There was no significant difference in the occurrence of adverse drug reactions between two groups (P ＞ 0.05).Conclusion Tropisetron combined with sulpiride than the routine use of tropisetron can obtain the better the antiemetic effect.
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Objective To observe the effect of tropisetron and tranquilizer on preventing nausea and vomiting induced by breast cancer chemotherapy,in comparison with using only tropisetron.Methods 78 cases of breast cancer patients undergoing chemotherapy were randomly divided into the observation group (40 cases) and the control group (38 cases).The observation group used the method of antiemetic intravenous tropisetron,while the control group adopted intravenous drip of tropisetron combined with intramuscular injection of chlorpromazine.The incidence of nausea and vomiting of two groups was observed.Results The incidence of nausea and vomiting of the observation group was higher than that of the control group.The incidence of adverse reaction showed no obvious difference between two groups.Conclusions Intravenous injection of tropisetron combined with intramuscular injection of chlorpromazine can reduce nausea and vomiting caused by chemotherapy of breast cancer,so this method is worthy of popularization.
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Objective To explore the clinical value of dexamethasone combined with tropisetron in preventing adverse reaction after laparoscopic surgery.Methods According to the sequence of admission,1 500 laparoscopic cholecystectomy patients were divided into the simple group and compound group.The simple group was administrated with tropisetron,and the compound group was administrated with dexamethasone combined with tropisetron.Results 24h after opration,the excellent and good rate of the simple group was 96％,which of the compound group was 100％,there were significant differences between the two groups (x2 =30.61,P ＜ 0.05) ; The adverse reaction severity score of the simple group was (4.1 ± 1.8) points,which of the compound group was (2.0 ± 1.1) points,there were significant differences between the two groups (t =27.26,P ＜ 0.05) ; The incidence rates of headache,dizziness,irritability of the compound group were lower than those of the simple group (x2 =94.35,26.79,78.95,all P ＜ 0.05).Conclusion Dexamethasone combined with tropisetron is effective after laparoscopic surgery to prevent adverse reactions occur,and effectively reduce the adverse reaction degree,has a high clinical value,is worth the clinical attention.
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OBJECTIVE: Agonists of alpha7-nicotinic acetylcholine receptors (nAChRs) have been developed as potential therapeutic drugs for neuropsychiatric diseases such as schizophrenia and Alzheimer's disease. Positron emission tomography (PET) is a noninvasive brain imaging technique to measure receptor occupancy in the living human brain. Although much effort has been expended to create specific PET radioligands for alpha7-nAChRs in the brain, only 4-[11C]methylphenyl-1,4-diazabicyclo[3.2.2.]nonane-4-carboxylate ([11C]CHIBA-1001) is currently available for clinical studies. In contrast, two 5-hydroxytryptamine-3 (5-HT3) receptor antagonists, tropisetron and ondansetron, have been used to treat patients with chemotherapy-induced or postoperative nausea and vomiting. Furthermore, tropisetron, but not ondansetron, possesses high affinity for alpha7-nAChRs. In the present study, we evaluated the receptor occupancy in the human brain after a single oral administration of tropisetron and ondansetron using [11C]CHIBA-1001 and PET. METHODS: Two serial dynamic PET scans using [11C]CHIBA-1001 in healthy non-smoking male subjects were performed before and after receiving an oral administration of these medications. RESULTS: A single oral administration of tropisetron, but not ondansetron, decreased the total distribution volume of [11C]CHIBA-1001 in the human brain. CONCLUSION: This study shows that tropisetron, but not ondansetron, could bind to alpha7-nAChRs in the human brain after a single oral administration. Therefore, [11C]CHIBA-1001 may be a useful PET radioligand to measure the occupancy of alpha7-nAChRs in the human brain.
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Humans , Male , Administration, Oral , Alzheimer Disease , Brain , Electrons , Indoles , Neuroimaging , Ondansetron , Positron-Emission Tomography , Postoperative Nausea and Vomiting , Receptors, Cholinergic , Receptors, Nicotinic , SchizophreniaABSTRACT
OBJECTIVE:To compare preventive effects of droperidol and tropisetron on nausea and vomiting after laparoscopic appendectomy.METHODS:60 patients with general anesthesia underwent elective laparoscopic appendectomy were randomly divided into group A,group B and group C (n=20).Before suture,group A received 0.9% sodium chloride injection 10 mL,group B droperidol 1.25 mg,group C tropisetron 5 mg.Patients were extubated as them became conscious.The occurrence of nausea and vomiting 24 h after operation were observed and recorded.RESULTS:The occurrence rate of postoperative nausea and vomiting in group B and group C were significantly lower than in group A (P0.05).CONCLUSION:Droperidol and tropisetron could significantly reduce the occurrence of nausea and vomiting after laparoscopic appendectomy.
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0.05).CONCLUSION:The domestic tropisetron hydrochloride is equivalent to the imported one in terms of the efficacy and safety in the treatment of cisplatin-induced nausea and vomiting.
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BACKGROUND: Thyroidectomy is associated with a relatively high incidence of postoperative nausea and vomiting (PONV) ranging from 63% to 84%. In this study, we evaluated the safety and the antiemetic effects of tropisetron 30 microgram/kg or tropisetron 30 microgram/kg plus dexamethasone 5 mg in patients undergoing thyroidectomy under a standard anesthetic technique without narcotics. METHODS: Sixty-eight patients undergoing thyroidectomy were randomized to receive a placebo (Group C, n = 28), tropisetron 30 microgram/kg (Group T, n = 23) or tropisetron 30 microgram/kg plus dexamethasone 5 mg (Group T + D, n = 17) IV over 2 5 minutes immediately before the induction of anesthesia. The effects of these regimens on the development of PONV, adverse events and need for rescue antiemetics were analyzed for the 0 to 1 hour and 1 to 24 hours postoperative periods. RESULTS: In the 0 to 1 hour postoperative periods, the incidence of PONV in group C, T and T + D was 35.7%, 17.4% and 17.6% respectively, which showed no significant difference among the three groups (P > 0.05). In the same period, the incidence of retching or vomiting in Group C, T and T + D was 14.3%, 0% and 0% respectively, which showed a significantly lower incidence in Group T and T + D than Group C (P 0.05). During the first 24 hours postoperatively, the overall incidences of PONV was 67.9% for group C, 60.9% for group T and 58.8% for group T + D, which showed no siginificant difference among the three groups (P > 0.05). Group T + D patients had more headache compared to other groups, but there was no significant difference in theincidences of overall adverse events. CONCLUSIONS: Neither tropisetron or tropisetron plus dexamethasone was significantly different from the placebo for the prevention of PONV after thyroidectomy during the first 24 hour postoperative period. Only vomiting during the first 1 hour postoperatively was prevented in the tropisetron and combination of tropisetron plus dexamethasone groups compared to the control group.
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Humans , Anesthesia , Antiemetics , Dexamethasone , Headache , Incidence , Narcotics , Postoperative Nausea and Vomiting , Postoperative Period , Thyroidectomy , VomitingABSTRACT
PURPOSE: Tropisetron, a new specific 5-hydroxytryptamine3 (5-HT3) receptor antagonist, is an effective antiemetic agent in the control of chemotherapy induced emesis with a long half life and bioavailablity. We compared the efficacy and safefy of Tropisetron and ondansetron to control emesis induced by highly emetogenic chemotherapeutics (cisplatin > or = 50 mg/m(2)). MATERIALS AND METHODS: Twenty-one patients were administered in a randomized, open, crossover study and received either tropisetron plus dexamethasone or ondansetron plus dexamethasone during two successive cycles of chemotherapy. RESULTS: Control of acute emesis with either tropisetron or ondansetron was 100% vs 95.2%, and 80.9% vs 76.2% in control of delayed emesis. Both severity and duration of nausea showed no statistically significant difference between tropisetron and ondansetron. Poor appetite and headache were most common side effects in both groups. CONCLUSION: There was no significant difference in efficacy for control of emesis and nausea between tropisetron and ondansetron in cisplatin-based chemotherapy.
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Humans , Antiemetics , Appetite , Cisplatin , Cross-Over Studies , Dexamethasone , Drug Therapy , Half-Life , Headache , Nausea , Ondansetron , VomitingABSTRACT
PURPOSE: Tropisetron (Nabovan (R)) is a new specific 5-HT3 receptor antagonist with a long terminal half life in plasma and high bioavailability after oral intake. We compared the antiemetic effectiveness and tolerability of tropisetron with ondansetron in the highly emetogenic chemotherapy (including cisplatin > or =50 mg/m2). MATERIALS AND METHODS: Thirty-nine patients were administered in a randomized, multicenter, open, cross-over study and received either tropisetron plus dexamethasone (n=31) or ondansetron plus dexamethasone (n=34) during six days of two successive cycles of chemotherapy. RESULTS: Total control of vomiting with either Ondansetron or tropisetron was 94.2 % vs 93.5 % in D1 (P=0.157); 90.6 % vs 93.1 % in D2 (P=0.18); 90.3 % vs 93.1 % in D3 (P=0.655); 96.4% vs 96.4 % in D4 (P=0.157); 96.4 % vs 100 % in D5 (P=0.317); 96.4 % vs 100% in D6, respectively. The duration of nausea showed significant decreasements in tropisetron at D5 and D6 (P=0.025, P=0.03, respectively), but the severity of nausea and performance status showed no significance. Headache and constipation were the most common side effects in both groups. CONCLUSION: There was no significant difference in efficacy and tolerability between tropisetron and ondansetron in the cisplatin-based chemotherapy.